Granulomatosis With Polyangiitis (GPA)

Granulomatosis with Polyangiitis (GPA), formerly known as Wegener’s granulomatosis, is a rare autoimmune disease characterized by inflammation of small- to medium-sized blood vessels (vasculitis) and the formation of granulomas, which are clusters of inflammatory cells. GPA most commonly affects the respiratory tract (sinuses, nose, and lungs) and the kidneys, but it can involve other organs as well. Symptoms may include chronic sinus infections, nasal congestion or nosebleeds, cough, shortness of breath, fatigue, joint pain, and kidney problems that can lead to blood in the urine.